The Science Museum of Camerino University was established by Rectorial Decree No. 476 on 19 October 1987 to promote scientific research, dissemination and museum education related to the natural history of the Marche Region and the central Apennines. 

The museum was relocated to the restored medieval complex of San Domenico on 30 May 30 2003. Within the new organisation of Unicam, the museum forms part of the Polo Museale together with the University Botanical Gardens.